Simulation-based education to promote confidence in managing clinical aggression at a paediatric hospital.

Background: An increasing number of incidents involving aggressive behaviour in acute care hospitals are being witnessed worldwide. Acute care hospital staff are often not trained or confident in managing aggression. Competent management of clinical aggression is important to maintain staff and patient safety.

Simulation-Based Education for Staff Managing Aggression and Externalizing Behaviors in Children With Autism Spectrum Disorder in the Hospital Setting: Pilot and Feasibility Study Protocol for a Cluster Randomized Controlled Trial.

Background: Children with autism spectrum disorder (ASD) frequently demonstrate aggression and externalizing behaviors in the acute care hospital environment. Pediatric acute care nursing staff are often not trained in managing aggression and, in particular, lack confidence in preventing and managing externalizing behaviors in children with ASD. High-fidelity simulation exercises will be used in this study to provide deliberate practice for acute care pediatric nursing staff in the management of aggressive and externalizing behaviors.

Marketing pharmaceutical drugs to women in magazines: a content analysis.

Objectives: To examine the prevalence and content of pharmaceutical ads in demographically different women's magazines.

Methods: A content analysis was conducted using one year's worth of 5 different women's magazines of varying age demographics.

Results: Magazines differed in the proportion of drug ads for different health conditions (eg, cardiovascular) and target audience by age demographic.

Ventilation and spontaneous breathing at birth of infants with congenital diaphragmatic hernia.

Objective: To describe the interaction of spontaneous breaths, manual ventilation, and tidal volumes (V(T)) during stabilization of infants with congenital diaphragmatic hernia (CDH) in the delivery room.

Study Design: We studied infants with CDH receiving respiratory support at birth. Airway pressure, flow, and volume were measured, and each breath or inflation was analyzed.

Signatures of molecular magnetism in single-molecule transport spectroscopy.

We report single-molecule-transistor measurements on devices incorporating magnetic molecules. By studying the electron-tunneling spectrum as a function of magnetic field, we are able to identify signatures of magnetic states and their associated magnetic anisotropy. A comparison of the data to simulations also suggests that sequential electron tunneling may enhance the magnetic relaxation of the magnetic molecule.

Pseudooctahedral complexes of vanadium(III): electronic structure investigation by magnetic and electronic spectroscopy.

A variety of physical methods has been used to probe the non-Kramers, S = 1, V(III) ion in two types of pseudooctahedral complexes: V(acac)(3), where acac = anion of 2,4-pentanedione, and VX(3)(thf)(3), where thf = tetrahydrofuran and X = Cl and Br. These methods include tunable frequency and high-field electron paramagnetic resonance (HFEPR) spectroscopy (using frequencies of approximately 95-700 GHz and fields up to 25 T) in conjunction with electronic absorption, magnetic circular dichroism (MCD), and variable-temperature variable-field MCD (VTVH-MCD) spectroscopies. Variable-temperature magnetic susceptibility and field-dependent magnetization measurements were also performed.

Raising the spin-reversal barrier in cyano-bridged single-molecule magnets: linear Mn(III)(2)M(III)(CN)(6) (M = Cr, Fe) species incorporating [(5-Brsalen)Mn](+) units.

Reactions between K(3)[M(CN)(6)] and [Mn(5-Brsalen)(H(2)O)(2)](+) (5-Brsalen = N,N'-ethylenebis(5-bromosalicylidene)aminato dianion) in a mixture of methanol and water afford the compounds K[(5-Brsalen)(2)(H(2)O)(2)Mn(2)M(CN)(6)].2H(2)O, with M = Cr (1) or Fe (2). The two compounds are isostructural, each containing a molecular cluster with a linear Mn(III)-NC-M(III)-CN-Mn(III) core and tetragonally elongated coordination about the Mn(III) centers.

Inhaled nitric oxide for acute hypoxic respiratory failure in children and adults: a meta-analysis.

We systematically reviewed randomized controlled trials examining inhaled nitric oxide (INO) for the treatment of acute respiratory distress syndrome or acute lung injury in children and adults. Qualitative assessments of identified trials were made, and metaanalyses were performed according to Cochrane methodology. Five randomized controlled trials (n = 535) met entry criteria.

Aprotinin conformational distributions during reversed-phase liquid chromatography. Analysis by hydrogen-exchange mass spectrometry.

Hydrogen-exchange mass spectrometry analysis of the stable protein aprotinin during reversed-phase liquid chromatography shows both native and unfolded protein. The behavior is consistent with only two conformational states, a near-native state and a fully solvent-accessible state, with reversible interchange of species within and between the mobile and stationary phases. The amount of unfolded form is greater on C18 relative to C4 alkyl modified silica surfaces.

High-nuclearity metal-cyanide clusters: synthesis, magnetic properties, and inclusion behavior of open-cage species incorporating [(tach)M(CN)3] (M = Cr, Fe, Co) complexes.

The use of 1,3,5-triaminocyclohexane (tach) as a capping ligand in generating metal-cyanide cage clusters with accessible cavities is demonstrated. The precursor complexes [(tach)M(CN)(3)] (M = Cr, Fe, Co) are synthesized by methods similar to those employed in preparing the analogous 1,4,7-triazacyclononane (tacn) complexes. Along with [(tach)Fe(CN)(3)](1)(-), the latter two species are found to adopt low-spin electron configurations.

A cyano-bridged single-molecule magnet: slow magnetic relaxation in a trigonal prismatic MnMo(6)(CN)(18) cluster.

We report the synthesis of the first well-documented example of a cyano-bridged single-molecule magnet. An assembly reaction parallel to that employed in producing the trigonal prismatic [(Me(3)tacn)(6)MnCr(6)(CN)(18)](2+) (Me(3)tacn = N,N',N"-trimethyl-1,4,7-triazacyclononane) cluster affords K[(Me(3)tacn)(6)MnMo(6)(CN)(18)](ClO(4))(3) (1), containing an analogous molybdenum(III)-substituted cluster. Fits to the DC magnetic susceptibility and magnetization data for 1 show that the MnMo(6) cluster possesses weak antiferromagnetic coupling (J = -6.

The Newborn Individualized Developmental Care and Assessment Program is not supported by meta-analyses of the data.

Objectives: To systematically review the effectiveness of the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) as compared with conventional care to improve long-term neurodevelopmental outcomes or short-term medical and neurodevelopmental outcomes in preterm and/or low birth weight infants.

Study Design: With the use of standard systematic review methodology, all randomized, controlled trials (RCTs) and prospective cohort studies evaluating in-hospital developmental care based on the framework of NIDCAP in preterm and/or low birth weight infants were identified. The quality of the RCTs was assessed.

Giant metal-cyanide coordination clusters: tetracapped edge-bridged cubic Cr(12)Ni(12)(CN)(48) and double face-centered cubic Cr(14)Ni(13)(CN)(48) species.

The crystal structures of two new metal-cyanide clusters with record high nuclearities are reported. A direct assembly reaction involving [(Me(3)tacn)Cr(CN)(3)] (Me(3)tacn = N,N',N"-trimethyl-1,4,7-triazacyclononane), NiI(2), and KCN in aqueous solution affords [(Me(3)tacn)(12)Cr(12)Ni(12)(CN)(48)](12+). The structure of this 24-metal cluster features a cube of eight Cr(III) centers linked along the edges by 12 trans-coordinated [Ni(CN)(4)](2)(-) units, and capped on four faces by [(Me(3)tacn)Cr](3+) moieties.

Fetal pulmonary artery diameters and their association with lung hypoplasia and postnatal outcome in congenital diaphragmatic hernia.

Objective: We hypothesized that fetal branch pulmonary artery (PA) diameters indirectly reflect lung mass and are associated with postnatal outcome in cases of isolated congenital diaphragmatic hernia (CDH).

Study Design: We retrospectively reviewed echocardiograms of fetuses with CDH, measuring branch PA diameters and other echocardiographic parameters. Antenatal parameters were correlated with postmortem lung weights in 5 fetuses after pregnancy termination.

Nickel(II)-molybdenum(III)-cyanide clusters: synthesis and magnetic behavior of species incorporating [(Me(3)tacn)Mo(CN)(3)].

The substitution of Mo(III) for Cr(III) in metal-cyanide clusters is demonstrated as an effective means of increasing the strength of the magnetic exchange coupling and introducing magnetic anisotropy. Synthesis of the octahedral complex [(Me(3)tacn)Mo(CN)(3)] (Me(3)tacn = N,N',N"-trimethyl-1,4,7-triazacyclononane) is accomplished with the addition of precisely 3 equiv of LiCN to a solution of [(Me(3)tacn)Mo(CF(3)SO(3))(3)] in DMF. An excess of LiCN prompts formation of a seven-coordinate complex, [(Me(3)tacn)Mo(CN)(4)](1)(-), whereas less LiCN produces multinuclear species such as [(Me(3)tacn)(2)Mo(2)(CN)(5)](1+).