Trends in Swallowing Outcomes Following Deintensified Treatment in Selected p16+ Oropharyngeal Carcinoma.

Objective: Identify trends in swallowing outcomes in p16+ oropharyngeal squamous cell carcinoma following neoadjuvant chemotherapy+surgery (NAC+S) versus neoadjuvant chemotherapy+surgery+radiation (NAC+S+R).

Study Design: Cohort study.

Setting: Single academic institution.

Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer.

Background: Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation.

Methods: All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment.

Results: The UW-QOL surveys were received from 25 of 48 eligible patients (52.

Swallowing Function Following Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Carcinoma: A 2-Year Follow-up.

Objective: To evaluate 2-year follow-up swallowing function in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) who completed neoadjuvant chemotherapy and transoral robotic surgery (NAC+S).

Study Design: Retrospective analysis of patients with OPSCC treated with NAC+S between 2010 and 2021.

Setting: A single academic institution.

How low can you go? Implant density in posterior spinal fusion converted from growing constructs for early onset scoliosis.

Study Design: Retrospective, multicenter comparative.

Objectives: Our purpose was to compare early onset scoliosis (EOS) patients treated with ultra-low, low, and high implant density constructs when undergoing conversion to definitive fusion. Larson et al.

Training Youth With SCI to Improve Efficiency and Biomechanics of Wheelchair Propulsion: A Pilot Study.

Long-term manual wheelchair users are at an increased risk of developing upper extremity (UE) joint pain and injuries due to the repetitive nature of wheelchair propulsion. Youth who sustain spinal cord injuries (SCIs) may be at even greater risk due to the many years they may be wheelchair dependent. There has been a decreasing trend in duration of initial rehabilitation, therefore little time is spent on training of proper wheelchair propulsion.

Despite limitations in content range, the SCIM-III is reproducible and a valid indicator of physical function in youths with spinal cord injury and dysfunction.

Study Design: Multi-center, repeated measures OBJECTIVES: Evaluate psychometric properties of the SCIM-III in children.

Setting: Seven facilities in North America METHODS: One-hundred and twenty-seven youths, mean age of 10.8 years and chronic spinal cord injury/dysfunction completed two administrations of the Spinal Cord Independence Measure-III (SCIM-III).

Paper #13: Early Onset Scoliosis: Results of Cotrel Mehta Casting from a Single Institution.

Early onset scoliosis can lead to significant chest wall deformity resulting in severe restrictive pulmonary disease and premature demise. Treatment of the spinal deformity should control the curvature but allow for continued growth of the spine and thorax. Serial derotational casting can potentially preserve and redirect spinal growth to achieve curve correction.

Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D.

Recommendations for mobility in children with spinal cord injury.

Background: Mobility is an important aspect of the rehabilitation of children with spinal cord injury (SCI), is a necessary component of life, and is critical in a child's development. Depending upon the individual's age and degree of neurological impairment, the nature of mobility may vary.

Objectives: The objective of this article is to establish recommendations surrounding the selection of mobility for children with SCI.

Spinal cord injuries in young children: a review of children injured at 5 years of age and younger.

Aim: To determine the epidemiology and complications of spinal cord injuries (SCIs) in children injured at 5 years of age and younger who were seen between 1981 and 2008 at a children's hospital in the USA.

Method: Complications studied were scoliosis, hip dysplasia, latex allergies, autonomic dysreflexia, pressure ulcers, spasticity, deep venous thrombosis, and kidney stones. Demographic and injury-related factors included age at injury, etiology, level of injury, American Spinal Injury Association Impairment Scale (AIS), and SCIs without radiological abnormalities (SCIWORA).

Ambulation in children and youth with spinal cord injuries.

Objective: To delineate the natural history of ambulation of children and youth with spinal cord injuries (SCls).

Design: Retrospective single-center.

Participants/methods: One hundred sixty-nine subjects who sustained SCI at 18 years of age or younger and who were followed up for at least 4 years.