Publications by authors named "Jennifer S Lozano"
Article Synopsis
- - The migration of epithelial cells is crucial for wound healing, impacted by various factors like mechanical disruption and interactions with the extracellular matrix.
- - Continuous activation of the epidermal growth factor receptor (EGFR) is essential for the healing process in corneal epithelial cell sheets.
- - A study indicates that wound edges serve as a significant cue for activating the EGFR and enhancing cell motility, independent of other factors, suggesting that the removal of physical constraints rather than specific cell interactions triggers this response.
Most formulations of artificial tears include high-molecular weight hydrophilic polymers (hydrogels) that are usually thought to serve to enhance viscosity and to act as demulcents. A few reports have indicated that application of some of the polymers accelerates healing of wounds in epithelia. Since activation of the epidermal growth factor (EGF) receptor is critical for spontaneous corneal epithelial wound healing, we tested commonly used hydrogels for their ability to activate the EGF receptor and enhance closure of wounds.
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