Publications by authors named "Jennifer R LaFontaine"
Article Synopsis
- Resident memory T cells (Ts) act as local defenders in tissues and can contribute to chronic inflammation, but their differentiation process and role in chronic kidney disease (CKD) remain unclear.
- In a study involving male C57BL/6J and OT-1 transgenic mice subjected to aristolochic acid (AA) injections, researchers observed a significant presence of Ts in the kidneys after CKD induction and identified key T cell surface markers and transcription factors.
- The findings suggest that Ts in the kidneys can develop through mechanisms that do not rely on standard antigen recognition, emphasizing the need for further investigation into their roles and generation processes in CKD contexts.
The kidney contains a population of resident macrophages from birth that expands as it grows and forms a contiguous network throughout the tissue. Kidney-resident macrophages (KRMs) are important in homeostasis and the response to acute kidney injury. While the kidney contains many microenvironments, it is unknown whether KRMs are a heterogeneous population differentiated by function and location.
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