Publications by authors named "Jennifer M Walters"
STriatal-Enriched protein tyrosine Phosphatase (STEP) is a brain-specific tyrosine phosphatase that is associated with numerous neurological and neuropsychiatric disorders. STEP dephosphorylates and inactivates various kinases and phosphatases critical for neuronal function and health including Fyn, Pyk2, ERK1/2, p38, and PTPα. Importantly, STEP dephosphorylates NMDA and AMPA receptors, two major glutamate receptors that mediate fast excitatory synaptic transmission.
View Article and Find Full Text PDFObjective: STriatal-Enriched protein tyrosine Phosphatase (STEP) is a brain-specific tyrosine phosphatase. Membrane-bound STEP is the only isoform expressed in hippocampus and cortex. Genetic deletion of STEP enhances excitatory synaptic currents and long-term potentiation in the hippocampus.
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- Polycystin 2 (PC2) is a calcium channel found on the endoplasmic reticulum and primary cilia in various cell types, primarily studied for its role in kidney function and its link to polycystic kidney disease (ADPKD).
- This study investigates how PC2 expression changes under different pathological conditions, revealing that its levels increase during cellular stress across multiple tissues.
- Findings suggest that PC2 plays a critical role in cellular protection, as cells lacking PC2 are more prone to stress-induced cell death, highlighting its importance in maintaining cell health in various diseases.