Geographic variation in the use of continuous outpatient inotrope infusion therapy and beta blockers.

Background: Continuous outpatient inotrope infusion therapy (COIIT) can be used as palliative or interim treatment in patients with advanced heart failure (AHF). Despite widespread use, there is a relative lack of data informing best practices. This study aimed to examine whether patterns of COIIT use differed by region and to explore whether observed differences influenced clinical outcomes.

Acute pulmonary pressure change after transition to sacubitril/valsartan in patients with heart failure reduced ejection fraction.

Aims: Sacubitril/valsartan combines renin-angiotensin-aldosterone system inhibition with amplification of natriuretic peptides. In addition to well-described effects, natriuretic peptides exert direct effects on pulmonary vasculature. The effect of sacubitril/valsartan on pulmonary artery pressure (PAP) has not been fully defined.

Multimodality Imaging of Danon Disease in a Patient with a Novel Mutation.

• Danon disease is a rare X-linked genetic disorder of the gene. • Danon cardiomyopathy has a high incidence of preexcitation and severe LVH. • mutation–associated cardiomyopathy can mimic sarcomeric HCM.