Elevated ghrelin predicts food intake during experimental sleep restriction.

Objective: Sleep curtailment has been linked to obesity, but underlying mechanisms remain to be elucidated. This study assessed whether sleep restriction alters 24-h profiles of appetite-regulating hormones ghrelin, leptin, and pancreatic polypeptide during a standardized diet and whether these hormonal alterations predict food intake during ad libitum feeding.

Methods: Nineteen healthy, lean men were studied under normal sleep and sleep restriction in a randomized crossover design.

Effects of sleep restriction on the human plasma metabolome.

This study examined the effects of recurrent sleep restriction on the plasma metabolome of adults with familial risk of type 2 diabetes. Eleven healthy adults (6M/5F; mean [SD] age: 26 [3]years; BMI 23.5 [2.

Sleep restriction decreases the physical activity of adults at risk for type 2 diabetes.

Study Objective: To test the hypothesis that recurrent sleep curtailment will result in decreased physical activity in adults at risk for type 2 diabetes.

Design: Two-condition 2-period randomized crossover study.

Setting: University General Clinical Research Center.

Sleep and eating behavior in adults at risk for type 2 diabetes.

Insufficient quantity and quality of sleep may modulate eating behavior, everyday physical activity, overall energy balance, and individual risk of obesity and type 2 diabetes. We examined the association of habitual sleep quantity and quality with the self-reported pattern of eating behavior in 53 healthy urban adults with parental history of type 2 diabetes (30 F/23 M; mean (s.d.

Insufficient sleep undermines dietary efforts to reduce adiposity.

Background: Sleep loss can modify energy intake and expenditure.

Objective: To determine whether sleep restriction attenuates the effect of a reduced-calorie diet on excess adiposity.

Design: Randomized, 2-period, 2-condition crossover study.

Sleep curtailment is accompanied by increased intake of calories from snacks.

Background: Short sleep is associated with obesity and may alter the endocrine regulation of hunger and appetite.

Objective: We tested the hypothesis that the curtailment of human sleep could promote excessive energy intake.

Design: Eleven healthy volunteers [5 women, 6 men; mean +/- SD age: 39 +/- 5 y; mean +/- SD body mass index (in kg/m(2)): 26.