Duodenal adenomas coincide with colorectal neoplasia.

Background And Aim: Small case series have alluded to an association between sporadic duodenal adenomas and colorectal neoplasia. The strength of the association remains uncertain. This case-control study was designed to test this association in a large national pathology database.

Prevalence of esophageal eosinophilia varies by climate zone in the United States.

Objectives: The epidemiology of eosinophilic esophagitis (EoE) is rapidly evolving, and differences in climate could impact the prevalence of EoE. We aimed to examine the association between esophageal eosinophilia and climate zones in the United States.

Methods: This was a cross-sectional study of esophageal biopsies from 2008 to 2010 in a large US pathology database.

Histopathologic diagnosis of eosinophilic conditions in the gastrointestinal tract.

Eosinophils, a constitutive component of the columnar-lined gastrointestinal tract, play an essential role in allergic responses and parasitic infections. The tissue density of these cells also increases in a variety of conditions of uncertain etiology. With the exception of the esophageal squamous epithelium, in which no eosinophils are normally present, the population of normal eosinophils in the remainder of the luminal gut is poorly defined.

Inverse association of esophageal eosinophilia with Helicobacter pylori based on analysis of a US pathology database.

Background & Aims: Eosinophilic esophagitis (EoE) is of increasing prevalence and believed to result from allergic processes. Helicobacter pylori has been inversely associated with allergic diseases, but there is no known relationship between H pylori, EoE, and esophageal eosinophilia. We investigated the association between esophageal eosinophilia and H pylori infection.