Cervicovaginal microbiome in twin vs singleton gestations.

Background: The vaginal microbiome diversity profile varies by race and ethnicity and changes considerably from the nonpregnant state to the pregnant state, specifically with a shift to Lactobacillus predominance in singleton gestations. There is a paucity of data that evaluate the cervicovaginal microbiome in women with twin gestations as a distinct population from those with singleton gestations.

Objective: We sought to characterize the cervicovaginal microbiome diversity profiles among twin gestations in the second trimester of pregnancy.