False-positive urine opiate screening associated with fluoroquinolone use.

Objective: To review the literature regarding false-positive urine opiate screens associated with the use of fluoroquinolones.

Data Sources: Literature was identified using MEDLINE (1966-February 2004), EMBASE, and all EBM Reviews with the terms quinolones, substance abuse detection, opiates, cross-reactions, false-positive reactions, and each fluoroquinolone. Article references were also reviewed.