Television depictions about dermatology and skin diseases in Seinfeld.

The iconic television situation comedy Seinfeld frequently referenced dermatologists and topics involving the integument, using satire for comedic effect. However, selecting satire to portray an already misunderstood and unknown subject matter may perpetuate incorrect public beliefs and stereotypes about those with skin diseases and diminish cultural sensitivity towards people who have dermatologic conditions and their caregivers.

The imbalanced expression of matrix metalloproteinases in nephrogenic systemic fibrosis.

Background: Nephrogenic systemic fibrosis (NSF) occurs in patients with renal dysfunction and gadolinium exposure. Although little is known about the pathogenesis of this disease, increased expression of transforming growth factor-beta has been recently demonstrated. Other fibrosing conditions have been shown to express an imbalance in matrix metalloproteinase (MMP) expression and their corresponding inhibitors.

Transitional cell neoplasm of the nasolacrimal duct associated with human papillomavirus type 11.

Background: Tumors of the lacrimal sac are rare but noteworthy because of their significant potential to become malignant or life-threatening if treatment is delayed. Dermatologists may be the first to encounter such neoplasms.

Observations: We report a case of a 53-year-old Caucasian woman who presented with a seven-year history of an asymptomatic, subcutaneous nodule near her right medial canthus.

Acute localized exanthematous pustulosis: a cutaneous drug reaction in a dental setting.

Background: Acute generalized exanthematous pustulosis is a severe cutaneous eruption caused most commonly by antibiotics. Rarely, a localized variant of this pustular reaction called "acute localized exanthematous pustulosis" has been described.

Case Description: A 29-year-old woman sought treatment at the authors' dermatology clinic for an outbreak of numerous superficial, nonfollicular pustules with an underlying erythematous base that was accompanied by subjective fever.