Maternal behavior modulates X-linked inheritance of behavioral coping in the defensive burying test.

Background: Complex behavioral traits such as coping strategies in response to stress are usually formed by genetic and environmental influences.

Methods: By exploiting the phenotypic and genotypic differences between the Wistar Kyoto (WKY) and Fischer 344 (F344) inbred rat strains, we recently identified three X chromosome-linked quantitative trait loci contributing to differences in coping strategies in the defensive burying (DB) paradigm. In this article we study the influence of postnatal maternal environment in these behaviors by characterizing the maternal behavior of these strains and the effect of cross-fostering on DB behavior of male offspring from reciprocal crossing (F1).