Publications by authors named "Jennifer L Lewis"
The insulin receptor is a phylogenetically ancient tyrosine kinase receptor found in organisms as primitive as cnidarians and insects. In higher organisms it is essential for glucose homeostasis, whereas the closely related insulin-like growth factor receptor (IGF-1R) is involved in normal growth and development. The insulin receptor is expressed in two isoforms, IR-A and IR-B; the former also functions as a high-affinity receptor for IGF-II and is implicated, along with IGF-1R, in malignant transformation.
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- A nine-locus STR multiplex system called GenePrint PowerPlex 2.1, developed by Promega, was tested alongside the Penta D locus to improve human identification accuracy.
- The system incorporates highly variable DNA loci and can work with the previously established PowerPlex 1.1 system, sharing some loci for quality control.
- Validation studies across seven laboratories confirmed the PowerPlex 2.1/Penta D system's efficiency, reproducibility, and reliability for forensic DNA testing, aligning with FBI quality assurance standards.