Publications by authors named "Jennifer L Darby"
Background: Major surgery triggers trauma-like stress responses linked to age, surgery duration, and blood loss, resembling polytrauma. This similarity suggests elective surgery as a surrogate model for studying polytrauma immune responses. We investigated stress responses across age groups and compared them with those of polytrauma patients.
View Article and Find Full Text PDFAdmission-based circulating biomarkers for the prediction of outcomes in trauma patients could be useful for clinical decision support. It is unknown which molecular classes of biomolecules can contribute biomarkers to predictive modeling. Here, we analyzed a large multi-omic database of over 8500 markers (proteomics, metabolomics, and lipidomics) to identify prognostic biomarkers in the circulating compartment for adverse outcomes, including mortality and slow recovery, in severely injured trauma patients.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to create a risk-adjustment model for hospitals to evaluate their performance in treating sepsis patients by analyzing 30-day mortality rates using administrative data from Pennsylvania hospitals in 2012-2013.
- - Researchers found significant variation in hospital-specific mortality rates for sepsis, ranging from 12.2% to 24.5%, and the model achieved strong accuracy with a C-statistic of 0.78.
- - The model showed that performance assessments remained stable over the two years studied, with a high correlation that indicates consistent ranking of hospitals in their care for sepsis patients.