Localized hydrogel delivery of dendritic cells for attenuation of multiple sclerosis in a murine model.

In multiple sclerosis (MS), abnormally activated immune cells responsive to myelin proteins result in widespread damage throughout the central nervous system (CNS) and ultimately irreversible disability. Immunomodulation by delivering dendritic cells (DCs) utilizes a potent and rapid MS disease progression driver therapeutically. Here, we investigated delivering DCs for disease severity attenuation using an experimental autoimmune encephalomyelitis preclinical MS model.

Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation.

Unlabelled: Although B cells are traditionally known for their role in propagating proinflammatory immune responses, their immunosuppressive effects have only recently begun to be appreciated. How these regulatory B cells (B) suppress the immune response remains to be worked out in detail. In this article, we show that B can induce the formation of conventional FoxP3 regulatory T cells (T), as well as a more recently described CD49bCD223 regulatory T-cell subset, known as type 1 regulatory T cells (Tr1s).