Cognition and Cortical Thickness in Heavy Cannabis Users.

Introduction: Acute and long-term adverse effects of heavy cannabis use (HCU) on neurocognitive function have been suggested, as much as regional changes of brain volume. However, little is known about the relationship between impaired cognition and brain structure in individuals with HCU.

Objective: Here, we investigated associations between cognition and cortical thickness (CT) in males with HCU and male controls.

A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression.

Verbal and visuospatial working memory (WM) impairment is a well-documented finding in psychiatric patients suffering from major psychoses such as schizophrenia or bipolar affective disorder. However, in major depression (MDD) the literature on the presence and the extent of WM deficits is inconsistent. The use of a multitude of different WM tasks most of which lack process-specificity may have contributed to these inconsistencies.