Mycoplasma-Induced Rash and Mucositis in a Father and Son: A Case Report.

This case report describes a father and son with recurrent Mycoplasma-induced rash and mucositis (MIRM). A father with a remote history of a similar rash in childhood presented to the hospital with a severe rash with mucosal involvement, and elevated Mycoplasma pneumoniae immunoglobulin M titers, consistent with MIRM. Four years later, a similar rash developed in his son with a positive M.

Self-limited neonatal periumbilical erythema.

We report three cases of neonatal, noninfectious, periumbilical erythema that resolved shortly after umbilical stump detachment. We hypothesize that these infants experienced an inflammatory and vasodilatory response during the normal umbilical cord separation process. We propose a new term: self-limited neonatal periumbilical erythema.

Patient viewing sessions: the patient experience.

Background Dermatology grand rounds and clinical conferences often include patient viewing sessions, during which groups of dermatologists and trainees see and discuss patient cases.Objective To understand experiences and attitudes of patients participating in patient viewing sessions.Methods Questionnaires were given to patients immediately before and after patient viewing sessions and by mail 3 months after participating in patient viewing sessions.

Bone marrow engraftment and associated dermatologic sequelae in a three-yr-old after liver transplantation.

We present a case of a three-yr-old child with a history of multisystem Langerhans cell histiocytosis treated with systemic chemotherapy, who developed progressive liver failure and received an orthotopic split liver transplant while continuing on chemotherapy. One month following transplant, he developed acute graft-vs.-host disease of the skin and gastrointestinal tract.

Mechanisms of action of etanercept in psoriasis.

Psoriasis is a chronic inflammatory disease of the skin affecting up to 2.5% of the world's population. The scaly, erythematous plaques characteristic of this papulosquamous disorder are likely triggered and maintained by cytokines and chemokines manufactured by cells of the immune system.

Induction of lesional and circulating leukocyte apoptosis by infliximab in a patient with moderate to severe psoriasis.

Infliximab demonstrates high efficacy in treating psoriasis in a high proportion of patients. In this report we demonstrate induction of plaque (T cells, dendritic cells) and peripheral blood (T cells, monocytes) leukocyte apoptosis following a single infliximab infusion in a psoriasis patient.

Etanercept induces apoptosis of dermal dendritic cells in psoriatic plaques of responding patients.

Background: Etanercept is a tumor necrosis factor-alpha binding fusion protein that demonstrates efficacy in the treatment of psoriasis, which is accompanied by decreased plaque infiltration of T cells and myeloid dendritic cells. We hypothesized that etanercept decreases inflammatory cell infiltration by inducing apoptosis.

Objective: We sought to investigate the effect of etanercept on circulating and plaque leukocyte apoptosis in psoriasis.