Assessing beliefs about emotion generation and change: The conceptualisation, development, and validation of the Cognitive Mediation Beliefs Questionnaire (CMBQ).

The ability to regulate emotions is important for human function and health. That emotion regulation can be achieved through cognitive change is predicated on the notion of cognitive mediation. However, the extent to which individuals believe that their emotions are cognitively mediated (C-M), or in contrast, that their emotions occur via stimulus-response (S-R), is underexplored, and whether C-M and S-R beliefs shape emotion reactivity is not yet known.

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.

Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo interrogation demonstrate that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis. Accordingly, suppression of DNA-PKcs inhibits tumor metastases.

Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D.