Negative pressure wound therapy: evidence-based treatment for complex diabetic foot wounds.

Negative pressure therapy is a novel technology used for the promotion of wound healing and has emerged as the standard care in the management of problem wounds. Negative pressure wound therapy has been met with rapid clinical success and widespread acceptance. The literature is replete with case series, small trials, and noncomparative studies; however, there are few prospective, randomized, human trials examining this technology and its ability to promote healing.