Publications by authors named "Jennifer J Lowinger"

The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2, are highly expressed in organs of first-pass metabolism and play an important role in xenobiotic metabolism. The current study was conducted to better understand species-related differences in substrate selectivity and tissue expression of these enzymes.

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Synopsis of recent research by authors named "Jennifer J Lowinger"

  • Jennifer J Lowinger's research focuses on the characterization of carboxylesterases, particularly CES1 and CES2, which are crucial enzymes involved in the metabolism of various xenobiotics in humans.
  • The study investigates the expression levels and activity of these enzymes across different species, including beagle dogs and cynomolgus monkeys, to understand species-related differences in substrate selectivity and tissue expression.
  • The findings highlight the significant role of CES1 and CES2 in first-pass metabolism in humans, which could have implications for drug metabolism and toxicity assessment in various species.

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