Publications by authors named "Jennifer I Alexander"
Article Synopsis
- Citizen science allows non-scientists to contribute to research, particularly in addressing issues relevant to their communities, typically designed by experienced scientists.
- Challenges arise when citizens try to design their own research due to limited training and access to necessary tools, which can lead to overlooked community experiences in health research.
- This approach engages participants from Grade 5 to adults in studying diet and disease using the genetics of Drosophila, empowering them to lead research projects and incorporate community relevance into the findings.
Stem cells cycle between periods of quiescence and proliferation to promote tissue health. In Drosophila ovaries, quiescence to proliferation transitions of follicle stem cells (FSCs) are exquisitely feeding-dependent. Here, we demonstrate feeding-dependent induction of follicle cell differentiation markers, eyes absent (Eya) and castor (Cas) in FSCs, a patterning process that does not depend on proliferation induction.
View Article and Find Full Text PDFSonic Hedgehog (Shh) is a tightly regulated membrane-associated morphogen and a known driver of tumorigenesis in pancreatic ductal adenocarcinoma (PDAC). After processing, Shh remains at the plasma membrane of Shh producing cells, thereby limiting its distribution and signal strength. In PDAC, the release of Shh from tumor cells is necessary to promote a tumor-permissive microenvironment.
View Article and Find Full Text PDF