Pathogenesis of renal disease due to enterohemorrhagic Escherichia coli in germ-free mice.

Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that causes hemorrhagic colitis and acute renal failure. We used a germ-free mouse model to investigate the role of host factors, Shiga toxin 2 (Stx2), and bacterial strain in disease due to EHEC. Germ-free male and female Swiss-Webster mice that were 3 days to 12 weeks old were orally inoculated with 1 of 10 EHEC strains or derivatives of two of these strains with Stx2 deleted.

Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice.

Gastritis due to Helicobacter pylori is induced by a Th1-mediated response that is CD4 cell and gamma interferon (IFN-gamma) dependent. T-bet is a transcription factor that directs differentiation of and IFN-gamma secretion by CD4+ Th1 T cells. The goal of this study was to use two mouse models to elucidate the role of T-bet in gastritis due to H.

Tibiotarsal fracture repair in a bald eagle (Haliaeetus leucocephalus) using an interlocking nail.

A 14-yr-old, 5.13-kg bald eagle (Haliaeetus leucocephalus) was hit by a car and presented to the Michigan State University Small Animal Clinic with an open, grade II, transverse, midshaft, Winquist-Hansen type-II-comminuted left tibiotarsal fracture. The fracture was reduced and fixation established with a 4.