Publications by authors named "Jennifer Earp"
Article Synopsis
- - Inflammatory bowel disease (IBD) is a chronic condition with limited treatments that can have negative side effects; researchers developed a targeted probiotic system (EcN) to potentially treat it.
- - This system uses a sensor to detect nitric oxide as a biomarker for inflammation and can secrete therapeutic nanobodies that work similarly to a common IBD drug, Adalimumab.
- - The study also created a mathematical model to help understand and optimize how these probiotics interact and function, enhancing the possibilities for future IBD therapies through synthetic biology.
The ongoing COVID-19 pandemic represents an unprecedented global health crisis. Here, we report the identification of a synthetic nanobody (sybody) pair, Sb#15 and Sb#68, that can bind simultaneously to the SARS-CoV-2 spike RBD and efficiently neutralize pseudotyped and live viruses by interfering with ACE2 interaction. Cryo-EM confirms that Sb#15 and Sb#68 engage two spatially discrete epitopes, influencing rational design of bispecific and tri-bispecific fusion constructs that exhibit up to 100- and 1,000-fold increase in neutralization potency, respectively.
View Article and Find Full Text PDFMycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important goal of tuberculosis research is to shorten the treatment to reduce the burden on patients, increase adherence to the drug regimen and thereby slow down the spread of drug resistance. Inhibition of drug efflux pumps by small molecules has been advocated as a promising strategy to attack persistent Mtb and shorten therapy.
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