Enhancing Radiologist Efficiency with AI: A Multi-Reader Multi-Case Study on Aortic Dissection Detection and Prioritization.

Background And Objectives: Acute aortic dissection (AD) is a life-threatening condition in which early detection can significantly improve patient outcomes and survival. This study evaluates the clinical benefits of integrating a deep learning (DL)-based application for the automated detection and prioritization of AD on chest CT angiographies (CTAs) with a focus on the reduction in the scan-to-assessment time (STAT) and interpretation time (IT).

Materials And Methods: This retrospective Multi-Reader Multi-Case (MRMC) study compared AD detection with and without artificial intelligence (AI) assistance.

Diagnostic Performance of a Deep Learning-Powered Application for Aortic Dissection Triage Prioritization and Classification.

This multicenter retrospective study evaluated the diagnostic performance of a deep learning (DL)-based application for detecting, classifying, and highlighting suspected aortic dissections (ADs) on chest and thoraco-abdominal CT angiography (CTA) scans. CTA scans from over 200 U.S.

Impact of an automated large vessel occlusion detection tool on clinical workflow and patient outcomes.

Purpose: Automated large vessel occlusion (LVO) tools allow for prompt identification of positive LVO cases, but little is known about their role in acute stroke triage when implemented in a real-world setting. The purpose of this study was to evaluate the automated LVO detection tool's impact on acute stroke workflow and clinical outcomes.

Materials And Methods: Consecutive patients with a computed tomography angiography (CTA) presenting with suspected acute ischemic stroke were compared before and after the implementation of an AI tool, RAPID LVO (RAPID 4.

Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke.

Methamphetamine use causes spikes in blood pressure. Chronic hypertension is a major risk factor for cerebral small vessel disease (cSVD). The aim of this study is to investigate whether methamphetamine use increases the risk of cSVD.

Head-to-head comparison of commercial artificial intelligence solutions for detection of large vessel occlusion at a comprehensive stroke center.

Purpose: Despite the availability of commercial artificial intelligence (AI) tools for large vessel occlusion (LVO) detection, there is paucity of data comparing traditional machine learning and deep learning solutions in a real-world setting. The purpose of this study is to compare and validate the performance of two AI-based tools (RAPID LVO and CINA LVO) for LVO detection.

Materials And Methods: This was a retrospective, single center study performed at a comprehensive stroke center from December 2020 to June 2021.

Autoimmune-mediated encephalitis and mimics: A neuroimaging review.

Autoimmune encephalitis is a category of autoantibody-mediated neurological disorders that often presents a diagnostic challenge due to its variable clinical and imaging findings. The purpose of this image-based review is to provide an overview of the major subtypes of autoimmune encephalitis and their associated autoantibodies, discuss their characteristic clinical and imaging features, and highlight several disease processes that may mimic imaging findings of autoimmune encephalitis. A literature search on autoimmune encephalitis was performed and publications from neuroradiology, neurology, and nuclear medicine literature were included.

Point-of-Care Brain MRI: Preliminary Results from a Single-Center Retrospective Study.

Background Point-of-care (POC) MRI is a bedside imaging technology with fewer than five units in clinical use in the United States and a paucity of scientific studies on clinical applications. Purpose To evaluate the clinical and operational impacts of deploying POC MRI in emergency department (ED) and intensive care unit (ICU) patient settings for bedside neuroimaging, including the turnaround time. Materials and Methods In this preliminary retrospective study, all patients in the ED and ICU at a single academic medical center who underwent noncontrast brain MRI from January 2021 to June 2021 were investigated to determine the number of patients who underwent bedside POC MRI.

Validation of a Deep Learning Tool in the Detection of Intracranial Hemorrhage and Large Vessel Occlusion.

Recently developed machine-learning algorithms have demonstrated strong performance in the detection of intracranial hemorrhage (ICH) and large vessel occlusion (LVO). However, their generalizability is often limited by geographic bias of studies. The aim of this study was to validate a commercially available deep learning-based tool in the detection of both ICH and LVO across multiple hospital sites and vendors throughout the U.

Impact of COVID-19 on Acute Stroke Presentation at a Comprehensive Stroke Center.

COVID-19 has impacted healthcare in many ways, including presentation of acute stroke. Since time-sensitive thrombolysis is essential for reducing morbidity and mortality in acute stroke, any delays due to the pandemic can have serious consequences. We retrospectively reviewed the electronic medical records for patients presenting with acute ischemic stroke at a comprehensive stroke center in March-April 2020 (the early months of COVID-19) and compared to the same time period in 2019.

Spot Sign in Secondary Intraventricular Hemorrhage Predicts Early Neurological Decline.

Purpose: The spot sign is associated with intracerebral hemorrhage (ICH) expansion and neurological decline. However, the relationship of the spot sign to secondary intraventricular hemorrhage (IVH) has not been well established. The presence of the spot sign in secondary IVH may provide information regarding neurologic outcome in a population with known poor prognosis.

Central Nervous System Vasculopathies.

Various imaging techniques play a role in the diagnosis of CNS vasculopathies, which comprise a heterogeneous group of disorders, including various noninflammatory and inflammatory etiologies. Noninflammatory vasculopathies include entities such as CADASIL, Susac, moyamoya, fibromuscular dysplasia, vasculopathy of connective tissue disorders, and reversible vasoconstriction syndrome. Inflammatory vasculopathies include vasculitides of different vessel sizes, primary angiitis of the CNS, vasculitis of systemic disease, and vasculitis secondary to specific causes.

Evaluation of neonatal brain myelination using the T1- and T2-weighted MRI ratio.

Purpose: To validate the T1- and T2-weighted (T1w/T2w) MRI ratio technique in evaluating myelin in the neonatal brain.

Materials And Methods: T1w and T2w MR images of 10 term neonates with normal-appearing brain parenchyma were obtained from a single 1.5 Tesla MRI and retrospectively analyzed.

Hypofractionated radiation therapy versus standard fractionated radiation therapy with concurrent temozolomide in elderly patients with newly diagnosed glioblastoma.

Purpose: Adjuvant hypofractionated radiation therapy (HRT) for elderly patients with newly diagnosed glioblastoma (GBM) is a reasonable option compared with standard fractionation radiation therapy (SFRT). Outcomes in patients receiving HRT in the presence of temozolomide (TMZ) compared with SFRT with TMZ are unclear. We examined HRT for GBM with TMZ in comparison to SFRT with TMZ.

A Modern Radiotherapy Series of Survival in Hispanic Patients with Glioblastoma.

Background: Studies have shown racial differences in cancer outcomes. We investigate whether survival differences existed in Hispanic patients with glioblastoma (GBM) compared with other ethnicities from our modern radiotherapy series, because no study to date has focused on outcomes in this group after radiation therapy.

Methods: We retrospectively evaluated 428 patients diagnosed with GBM from 1996 to 2014 at our institution, divided into 4 groups based on self-report: white, black, Hispanic, and Asian/Indian.

Timing of Adjuvant Radiotherapy in Glioblastoma Patients: A Single-Institution Experience With More Than 400 Patients.

Background: The standard of care for patients with newly diagnosed glioblastoma (GBM) is maximal safe resection followed by adjuvant radiation therapy (RT) and temozolomide (TMZ).

Objective: To investigate whether the timing of adjuvant RT after surgery affected outcome in patients with GBM.

Methods: We retrospectively reviewed all patients with a diagnosis of GBM at our institution.

Opioids in the hypothalamic paraventricular nucleus stimulate ethanol intake.

Background: Specialized hypothalamic systems that increase food intake might also increase ethanol intake. To test this possibility, morphine and receptor-specific opioid agonists were microinjected in the paraventricular nucleus (PVN) of rats that had learned to drink ethanol. To cross-validate the results, naloxone methiodide (m-naloxone), an opioid antagonist, was microinjected with the expectation that it would have the opposite effect of morphine and the specific opioid agonists.

Opioids in the nucleus accumbens stimulate ethanol intake.

The nucleus accumbens (NAc) participates in the control of both motivation and addiction. To test the possibility that opioids in the NAc can cause rats to select ethanol in preference to food, Sprague-Dawley rats with ethanol, food, and water available, were injected with two doses each of morphine, the mu-receptor agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-Enkephalin (DAMGO), the delta-receptor agonist D-Ala-Gly-Phe-Met-NH2 (DALA), the k-receptor agonist (+/-)-trans-U-50488 methanesulfonate (U-50,488H), or the opioid antagonist naloxone methiodide (m-naloxone). As an anatomical control for drug reflux, injections were also made 2mm above the NAc.