Publications by authors named "Jennifer E Li"
Neurobiol Aging
February 2021
Article Synopsis
- Sensorimotor performance declines with age, partly due to reduced somatosensory acuity and changes in excitability and inhibition of neurons in the primary somatosensory cortex (S1).
- Researchers examined vibrissal S1 neurons in young and aged mice, focusing on adapting and non-adapting pyramidal neurons in layer 5 (L5).
- They found that aging increased intrinsic excitability and decreased inhibition in both neuron types, with distinct effects: adapting neurons had a lower action potential threshold, while non-adapting neurons exhibited increased excitability due to higher input resistance and decreased synaptic inhibition.
