Publications by authors named "Jennifer E Baum"
Article Synopsis
- * LPSs vary in differentiation grade, affecting prognosis and metastasis risk, with recent findings suggesting that overexpression of Gli2 in dedifferentiated liposarcoma (DDLPS) cells hinders adipogenic differentiation and promotes osteoblast markers.
- * The study also revealed changes in cytokine expression and macrophage populations in the tumor environment, specifically an increase in M2-like macrophages, suggesting that Gli2 influences both tumor cell differentiation and immune interactions in lip
The establishment and progression of bone metastatic breast cancer is supported by immunosuppressive myeloid populations that enable tumor growth by dampening the innate and adaptive immune response. Much work remains to understand how to target these tumor-myeloid interactions to improve treatment outcomes. Noncanonical Hedgehog signaling is an essential component of bone metastatic tumor progression, and prior literature suggests a potential role for Hedgehog signaling and its downstream effector Gli2 in modulating immune responses.
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