Publications by authors named "Jennifer Dawe"
Next generation DNA sequencing (NGS) has the potential to improve the diagnostic and prognostic utility of newborn screening programmes. This study assesses the feasibility of automating NGS on dried blood spot (DBS) DNA in a United Kingdom National Health Service (UK NHS) laboratory. An NGS panel targeting the entire coding sequence of five genes relevant to disorders currently screened for in newborns in the UK was validated on DBS DNA.
View Article and Find Full Text PDFSoy protein concentrates and soy protein isolates act as ingredients in bakery, meat and dairy products, baby formulas, starting materials for spun textured vegetable products, and other nutritional supplements. In this study, the effectiveness of a liquid-solid circulating fluidized bed (LSCFB) ion exchanger is demonstrated for the recovery of soluble soy proteins from full fat and defatted soy flour. Under steady-state operating conditions, about 50% of the proteins could be recovered from the feed streams entering the ion exchanger.
View Article and Find Full Text PDFArticle Synopsis
- A comparison of active sites in beta-ketoacyl synthases (KAS) and similar enzymes shows significant differences in geometry and function of catalytic residues.
- A specific template derived from KAS I and II enzymes accurately identifies their family members without false positives.
- The catalytic roles of histidines vary between different KAS types and related enzymes, with a less specific template that includes only cysteine and one histidine yielding many irrelevant matches.