Publications by authors named "Jennifer D Bright"

Article Synopsis
  • Cancer immunotherapy harnesses the immune system to target and destroy tumors, with new strategies focusing on vaccines against tumor-specific antigens, like the D52 protein.
  • Recent studies show that IL-10 deficiency in mice vaccinated with D52 leads to a stronger memory response against tumors than in normal mice, suggesting unique regulatory roles for certain T cell subtypes.
  • Analysis of T cells from vaccinated mice reveals that IL-10 producing CD8+ T cells, which exhibit specific markers, may function to suppress immune responses, impacting long-term tumor immunity.
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Development of cancer vaccines targeting tumor self-antigens is complex and challenging due to the difficulty of overcoming immune tolerance to self-proteins. Vaccination against tumor self-protein D52 (D52) has been successful, although complete protection appears impaired by immune regulation. Our previous studies suggest that vaccine elicited CD8 + T cells producing interleukin 10 (IL-10) may have a negative impact on tumor protection.

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Overexpressed tumor-self antigens represent the largest group of candidate vaccine targets. Those exhibiting a role in oncogenesis may be some of the least studied but perhaps most promising. This review considers this subset of self antigens by highlighting vaccine efforts for some of the better known members and focusing on TPD52, a new promising vaccine target.

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Tumor protein D52 (D52) is constitutively expressed in healthy tissues and overexpressed in multiple cancers, including (but not limited to) breast, prostate and ovarian carcinomas. Although the normal functions of D52 are unknown, it is clear that increased D52 expression levels not only stimulate cell proliferation and metastasis, but also correlate with poor prognosis in a subset of breast cancer patients. The murine orthologs of D52 (mD52) shares 86% identity with its human counterpart (hD52) and mirrors hD52 expression patterns.

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