Development of a novel patient-reported outcome measure for disseminated coccidioidomycosis (valley fever).

Background: Coccidioidomycosis (Valley Fever) is a dimorphic fungal infection endemic to the southwest United States, Mexico, Central and South America, which can lead to chronic debilitating illness and death.

Objectives: This qualitative study was conducted to develop a bespoke patient-reported outcome measure for patients with chronic disseminated coccidioidomycosis to assess health-related quality of life (HRQoL) impacts.

Patients And Methods: Online, first-person narratives of patient experiences of disseminated coccidioidomycosis were used to create a patient-centred conceptual model of symptoms and impacts of the condition.

Why wearing a yellow hat is impossible: Chinese and U.S. children's possibility judgments.

When thinking about possibility, one can consider both epistemic and deontic principles (i.e., physical possibility and permissibility).

Long-lasting otic solution containing mometasone furoate can influence intradermal testing in dogs with healthy ears and otitis externa.

Background: Topical therapy is preferred for otitis externa (OE) in dogs. Otic products commonly contain glucocorticoids that can be systemically absorbed and possibly interfere with diagnostic tests such as intradermal testing (IDT).

Hypothesis/objectives: To determine the effect of a long-lasting otic solution containing mometasone furoate (MF) on IDT immediate reactions and to determine withdrawal time before IDT.

Development of a Novel Patient-Reported Outcome Measure to Assess Symptoms and Impacts of Androgen Deprivation Therapy for Advanced Prostate Cancer.

Introduction: This qualitative research study was conducted to develop a novel, comprehensive, patient-reported outcome measure (PRO), the "Symptoms and Impacts of Androgen Deprivation Therapy (ADT) for Prostate Cancer" (SIADT-PC), assessing hormonal therapy-related symptoms and their impacts on men with advanced prostate cancer.

Methods: Concept elicitation (CE) interviews were conducted among adult men with prostate cancer to evaluate their experiences with ADT. Based on key symptom and impact concepts mentioned, an initial PRO measure was developed.

Tolerability of Otic Solutions Containing Different Enrofloxacin Concentrations in Dogs with Healthy Ears.

Otitis externa (OE) is a common disease in dogs, and topical medications are the preferred treatment. Compounded solutions of enrofloxacin are commonly used in practice to treat bacterial OE; however, the tolerability of different concentrations of this antibiotic in the ear canals of dogs has not been evaluated. The objective of this study is to determine if a higher concentration of enrofloxacin applied to the external ear canal is clinically tolerated in dogs with healthy ears.

Expressions of uncertainty in invisible scientific and religious phenomena during naturalistic conversation.

Across cultures, studies report more confidence in the existence of unobservable scientific phenomena, such as germs, as compared to unobservable religious phenomena, such as angels. We investigated a potential cultural mechanism for the transmission of confidence in the existence of invisible entities. Specifically, we asked whether parents in societies with markedly different religious profiles-Iran and China-signal differential confidence across the domains of science and religion during unmoderated conversations with their children (N = 120 parent-child dyads in total; 5- to 11-year-olds).

Otitis media with effusion in two Boston terrier dogs.

Otitis media (OM) in dogs can occur as a primary condition instead of as an extension of an otitis externa (OE), characterized by the presence of fluid in the middle ear (ME) referred to as OM with effusion (OME). OME has been reported in a brachycephalic breed (boxer), and the same condition is described as primary secretory OM in Cavalier King Charles Spaniels. These dogs can be asymptomatic or present with pain, facial nerve paralysis and reduced hearing.

Everyone's a Critic (Sometimes): Young Children Show High Awareness of, But Lower Adherence to, Prosocial Lying Norms.

From an early age, children are taught norms about socially-acceptable behaviors; however, children's ability to recognize these norms often predates their tendency to follow them. This conflict between understanding and action has been predominantly studied in cases when enacting the norm would be costly for the child (i.e.

Culture is an optometrist: Cultural contexts adjust the prescription of social learning bifocals.

The "prescription" of humans' social learning bifocals is fine-tuned by cultural norms and, as a result, the readiness with which the instrumental or conventional lenses are used to view behavior differs across cultures. We present evidence for this possibility from cross-cultural work examining children's imitation and innovation.

Cognitive flexibility supports the development of cumulative cultural learning in children.

The scale of cumulative cultural evolution (CCE) is a defining characteristic of humans. Despite marked scientific interest in CCE, the cognitive underpinnings supporting its development remain understudied. We examined the role cognitive flexibility plays in CCE by studying U.

Content validity of a newly developed observer-reported measure for pediatric asthma in children aged 2-5 years.

Background: An observer-reported outcome (ObsRO) measure assessing both symptom control and health-related quality of life (HRQoL) in children with asthma younger than 6 years is lacking. The objective of this study was to evaluate the content validity of the Pediatric Asthma Questionnaire (PAQ), a newly developed 6-item ObsRO measure for caregivers of children aged 2-5 years diagnosed with asthma.

Results: In-depth, qualitative interviews were conducted with 15 parents or caregivers.

Miraculous, magical, or mundane? The development of beliefs about stories with divine, magical, or realistic causation.

Children's naïve theories about causal regularities enable them to differentiate factual narratives describing real events and characters from fictional narratives describing made-up events and characters (Corriveau, Kim, Schwalen, & Harris, Cognition 113 (2): 213-225, 2009). But what happens when children are consistently presented with accounts of miraculous and causally impossible events as real occurrences? Previous research has shown that preschoolers with consistent exposure to religious teaching tend to systematically judge characters involved in fantastical or religious events as real (Corriveau et al., Cognitive Science, 39 (2), 353-382, 2015; Davoodi et al.

Children's Ideas About What Can Really Happen: The Impact of Age and Religious Background.

Five- to 11-year-old U.S. children, from either a religious or secular background, judged whether story events could really happen.

If I told you everyone picked that (non-affordant) tool, would you? Children attend to conventional language when imitating and transmitting tool use.

This study explored how conventional versus instrumental language influenced children's imitation and transmission of non-affordant tool use. Rather than examining children's imitation of unnecessary actions that do not impede goal completion, we examined children's conformity with a modeled behavior that may result in sacrificing goal completion. Children (N = 96 4- to 6-year-olds) were presented with either a conventional or instrumental description of a model's actions before watching the model choose a non-affordant tool.

A qualitative study to explore symptoms and impacts of pediatric and adolescent Crohn's disease from patient and caregiver perspective.

Background: Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract that affects people across the age spectrum but often starts in childhood or early adulthood. Despite this, almost all published research examining the symptomatic and health-related quality of life (HRQL) experiences of CD has been conducted in an adult population. Studies providing a comprehensive overview of the lived experience of pediatric and adolescent CD are virtually non-existent.

Teaching Through Collaboration: Flexibility and Diversity in Caregiver-Child Interaction Across Cultures.

Teaching supports the high-fidelity transmission of knowledge and skills. This study examined similarities and differences in caregiver teaching practices in the United States and Vanuatu (N = 125 caregiver and 3- to 8-year-old child pairs) during a collaborative problem-solving task. Caregivers used diverse verbal and nonverbal teaching practices and adjusted their behaviors in response to task difficulty and child age in both populations.

Are high levels of religiosity inconsistent with a high valuation of science? Evidence from the United States, China and Iran.

We asked whether high levels of religiosity are inconsistent with a high valuation of science. We explored this possibility in three countries that diverge markedly in the relation between the state and religion. Parents in the United States (n = 126), China (n = 234) and Iran (n = 77) completed a survey about their personal and parental stance towards science.

Patient-reported outcomes in paediatric cancer survivorship: a qualitative study to elicit the content from cancer survivors and caregivers.

Objectives: Content elucidation for patient-reported outcomes (PROs) in paediatric cancer survivorship is understudied. We aimed to compare differences in the contents of five PRO domains that are important to paediatric cancer survivorship through semistructured interviews with paediatric cancer survivors and caregivers, and identified new concepts that were not covered in the item banks of the Patient-Reported Outcomes Measurement Information System (PROMIS).

Design: Semistructured interviews to collect qualitative PRO data from survivors and caregivers.

Epistemic justifications for belief in the unobservable: The impact of minority status.

Children hold beliefs about religious and scientific entities, such as angels or germs, that they cannot directly observe or interact with. Given their limited opportunities for first-hand observation, children's beliefs in these entities are a clear example of cultural learning and are likely to vary based on cultural factors. In the present study, we investigated variation in the epistemic stance of 4-11-year-old children growing up in a religious minority in China (N = 47), a religious majority in Iran (N = 85), and a religious majority in the U.

Establishing the content validity of PROMIS Pediatric pain interference, fatigue, sleep disturbance, and sleep-related impairment measures in children with chronic kidney disease and Crohn's disease.

Background: PROMIS Pediatric patient-reported outcome measures were developed with children from the general population, and their content validity has not been established in children with chronic disease. This study was done to evaluate the content validity of the PROMIS Pediatric Pain Interference and Fatigue measures in children 8-17 years-old with Crohn's disease and the PROMIS Pediatric Fatigue, Sleep Disturbance, and Sleep-related Impairment measures for children 8-17 years-old with chronic kidney disease.

Methods: We conducted semi-structured interviews with individuals affected by Crohn's disease and chronic kidney disease.

Religious testimony in a secular society: Belief in unobservable entities among Chinese parents and their children.

When learning about the existence of unobservable scientific phenomena such as germs or religious phenomena such as God, children are receptive to the testimony of other people. Research in Western cultures has shown that by 5 to 6 years of age, children-like adults-are confident about the existence of both scientific and religious phenomena. We examined the beliefs of secular and Christian children growing up in China as well as the beliefs of their parents.

Trust me, I'm a competent expert: Developmental differences in children's use of an expert's explanation quality to infer trustworthiness.

In this study, we examined how 3-, 4-, 5-, and 7-year-old children respond when informants who are labeled as experts fail to provide high-quality explanations about phenomena within their realm of expertise. We found that 4-, 5-, and 7-year-olds discounted their initial trust in an expert who provided low-quality explanations in a task related to the expert's area of expertise. The 5-year-olds' distrust of the expert who provided low-quality explanations also generalized to additional learning tasks.

God, Germs, and Evolution: Belief in Unobservable Religious and Scientific Entities in the U.S. and China.

Adults in the U.S. and China were asked to make judgments about the existence of a variety of scientific and religious entities, including God, germs, and evolution.

Importance ratings on patient-reported outcome items for survivorship care: comparison between pediatric cancer survivors, parents, and clinicians.

Purpose: To compare importance ratings of patient-reported outcomes (PROs) items from the viewpoints of childhood cancer survivors, parents, and clinicians for further developing short-forms to use in survivorship care.

Methods: 101 cancer survivors, 101 their parents, and 36 clinicians were recruited from St. Jude Children's Research Hospital.

Children begin with the same start-up software, but their software updates are cultural.

We propose that early in ontogeny, children's core cognitive abilities are shaped by culturally dependent "software updates." The role of sociocultural inputs in the development of children's learning is largely missing from Lake et al.'s discussion of the development of human-like artificial intelligence, but its inclusion would help move research even closer to machines that can learn and think like humans.