Publications by Jennifer C Zimmer

Publications by authors named "Jennifer C Zimmer"

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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.

Robbie L McLeod Deen B Tulshian Donald C Bolser Geoffrey B Varty Marco Baptista Jennifer C Zimmer

Eur J Pharmacol

March 2010

We describe the pharmacological and pharmacokinetic profiles of SCH 486757, a nociceptin/orphanin FQ peptide (NOP) receptor agonist that has recently entered human clinical trials for cough. SCH 486757 selectively binds human NOP receptor (K(i)=4.6+/-0.

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Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.

Robbie L McLeod Deen B Tulshian Ginny D Ho Xiomara Fernandez Donald C Bolser Jennifer C Zimmer

Pharmacology

December 2009

Article Synopsis

Nociceptin/orphanin FQ (N/OFQ) and its receptor, NOP, play a role in inhibiting coughs, leading to interest in SCH 225288, a nonpeptide NOP agonist that could offer new cough treatments.
The study first confirmed that SCH 225288 selectively binds to the NOP receptor in human tests, then it assessed its cough-suppressing effects across three different animal models.
Results showed that SCH 225288 effectively suppressed cough in guinea pigs, cats, and dogs, and its effects were specifically linked to the NOP receptor rather than classical opioid receptors.

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