Publications by authors named "Jennifer C Pharr"
J Clin Oncol
December 2023
Article Synopsis
- This study investigates the genetic factors contributing to inherited lung cancer, focusing on families with germline pathogenic variants (PVs).
- Over a 5-year period, 141 participants with lung cancer and their relatives were enrolled, revealing a significant Mendelian inheritance pattern of the T790M variant with varied cancer penetrance.
- The findings highlight a recent common ancestor for the T790M variant primarily found in the southeastern U.S., suggesting the need for targeted screening in at-risk families, as many carriers showed high occurrences of lung cancer and related health issues.
