Publications by authors named "Jennifer Brach"

Background: Some older adults benefit to a great degree from walking interventions and others experience little improvement. Understanding the personal characteristics associated with greater treatment response to different interventions could assist clinicians in providing patients with matched interventions to optimize both outcomes and resource use.

Research Question: What personal characteristics are associated with improved gait speed for older adults participating in walking interventions?

Methods: This was a secondary analysis of 236 older adults from a trial comparing "Standard" (lower-extremity strength and walking endurance) to "Plus" (additional task-specific training for walking) interventions on gait speed in older adults (≥65 years).

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: Independent Living residences for older adults can be divided into two categories and require better definitions for research purposes; the purpose of this manuscript is to provide those definitions and explore variation in provided services and resident characteristics: (a) age-based housing (55+) (Department of Housing and Urban Development (HUD) housing units for low-income adults), and (b) age-based housing. Residents in the two settings were compared: 37 subsidized locations ( = 289 residents) and 19 non-subsidized ( = 208). Aging support services in each housing type were quantified.

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We evaluate the implementation of evidence-based falls prevention programs (EBFPPs) of the Administration for Community Living (ACL) Grantees by (1) describing adoption; (2) evaluating implementation through participant adherence; and (3) describing program maintenance. Secondary data analysis of a national data repository included forty-four ACL grantees spanning 31 states who were funded between September 2014 and December 2019 and provided information on over 80,000 older adult participants. Descriptive statistics including frequencies, percentages, and means were used to describe adoption, implementation (adherence), and maintenance of EBFPPs.

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Background: On the Move (OTM), a group exercise program to improve mobility in older adults, is efficacious when delivered by research staff. The next step in the development of OTM as a fully implementable intervention is to conduct an effectiveness study in which the intervention is delivered in community settings by community providers.

Methods: We describe the methods of a hybrid 1 cluster randomized, single-blind, intervention trial to compare the effectiveness of OTM to a delayed intervention control in 502 community-dwelling older adults across 44 sites.

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Objective: To evaluate the feasibility and preliminary efficacy of the transition of an outpatient center-based rehabilitation program for middle and older aged Veterans with mobility limitations to a tele-health platform.

Design: Non-randomized non-controlled pilot study including 10 treatment sessions over 8 weeks and assessments at baseline, 8, 16, and 24 weeks.

Setting: VA Boston Healthcare System ambulatory care between August 2020 and March 2021.

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Objective: Activity and participation are important for older adults as they are associated with well-being and quality of life. Falls, emergency department (ED) visits, and hospitalizations are adverse health outcomes that impact older adults. Limited research has investigated whether measurement of activity and participation are related to adverse health events in community dwelling older adults.

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Background: Neighborhood walkability may encourage greater out-of-home travel (ie, community mobility) to support independent functioning in later life. We examined associations between a novel walkability audit index and Global Positioning System (GPS)-derived community mobility in community-dwelling older adults. We compared associations with the validated Environmental Protection Agency (EPA) National Walkability Index and further examined moderation by clinical walking speed.

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Background: Physical activity and exercise are important aspects of maintaining health. People with mobility impairments, including survivors of stroke, are less likely to exercise and at greater risk of developing or worsening chronic health conditions. Increasing accessible, desired options for exercise may address the gap in available physical activity programs, provide an opportunity for continued services after rehabilitation, and cultivate social connections for people after stroke and others with mobility impairments.

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Background: Higher prefrontal cortex (PFC) activation while walking may indicate reduced gait automaticity.

Aim: We examine whether PFC activation during walking improves after training in older adults at risk for mobility disability.

Methods: Forty-two adults aged ≥ 65 participated in a randomized clinical trial (NCT026637780) of a 12-week timing and coordination physical therapy intervention to improve walking (n = 20 intervention, n = 22 active control).

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Background: Gait impairment leads to increased mobility decline and may have neurological contributions. This study explores how neurological biomarkers are related to gait in older adults.

Methods: We studied participants in the Cardiovascular Health Study, a population-based cohort of older Americans, who underwent a serum biomarker assessment from samples collected in 1996-1997 for neurofilament light chain (NfL), glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1, and total tau (n = 1 959, mean age = 78.

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Background: Using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, we describe the implementation of evidence-based chronic disease self-management education (CDSME) programs by the Administration for Community Living CDSME Grantees during 2016-2022 and we also explore the impact of the COVID-19 pandemic on implementation.

Methods: Grantees collected data before and after the implementation of the CDSME programs and contributed to the national data repository. Data components included workshop information, participant information, and organizational data.

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Background: Fear of Falling (FOF) is common among community-dwelling older adults and is associated with increased fall-risk, reduced activity, and gait modifications.

Objective: In this cross-sectional study, we examined the relationships between FOF and gait quality.

Methods: Older adults (N=232; age 77±6; 65 % females) reported FOF by a single yes/no question.

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Background: We examined the relationship between global positioning system (GPS) indicators of community mobility and incident hospitalizations, emergency department (ED) visits, and falls over 1-year in community-dwelling older adults.

Methods: We performed a secondary analysis of a randomized trial investigating a physical therapy intervention to improve mobility in older adults. One hundred and forty-eight participants (mean age: 76.

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Background: Real-world mobility involves walking in challenging conditions. Assessing gait during simultaneous physical and cognitive challenges provides insights on cognitive health.

Research Question: How does uneven surface, cognitive task, and their combination affect gait quality and does this gait performance relate to cognitive functioning?

Methods: Community-dwelling older adults (N = 104, age=75 ± 6 years, 60 % females) performed dual-task walking paradigms (even and uneven surface; with and without alphabeting cognitive task (ABC)) to mimic real-world demands.

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Objective: Walking is a key component of daily-life mobility. We examined associations between laboratory-measured gait quality and daily-life mobility through Actigraphy and Global Positioning System (GPS). We also assessed the relationship between two modalities of daily-life mobility i.

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Article Synopsis
  • - The study compared two intervention types (standard strength/endurance vs. standard plus timing/coordinating training) to see their effects on community mobility in older adults, using GPS tracking and Life Space Assessment (LSA) scores for measurement.
  • - 166 participants were monitored, and results showed no significant changes in community mobility over time or between the two groups, indicating that neither intervention was effective on its own.
  • - The authors concluded that focusing solely on physical function might not enhance community mobility, and suggested future research should develop more comprehensive interventions for older adults.
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Objectives: To develop and test implementation strategies to support implementing the Centers for Disease Control and Preventions' Stopping Elderly Accidents, Deaths, and Injuries (STEADI) initiative for falls prevention and falls risk management in a novel setting, outpatient physical therapy.

Design: A feasibility implementation study engaging key partners involved in or affected by the implementation throughout the study.

Setting: Five outpatient physical therapy clinics embedded in a health system.

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Background: Early change in function in older adults has been termed preclinical disability (PCD). PCD has been understudied compared to other stages of disability because it is unlikely to receive comparative priority in clinical settings. It has major implications for prevention and population health as it may be the optimal time to intervene to prevent further decline.

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Article Synopsis
  • - The review aimed to analyze how exercise impacts muscle quality in healthy older adults and those with neurological conditions, focusing on changes in morphological and neuromuscular quality.
  • - Researchers reviewed 30 studies involving nearly 1500 participants, finding that exercise had small positive effects on morphological muscle quality but notable improvements in neuromuscular muscle quality across various abilities.
  • - Results indicated that while exercise training effectively improved neuromuscular quality, there was no significant relationship between changes in muscle morphology and functional outcomes, nor did demographic factors affect these improvements.
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Research on aging is at an important inflection point, where the insights accumulated over the last 2 decades in the basic biology of aging are poised to be translated into new interventions to promote health span and improve longevity. Progress in the basic science of aging is increasingly influencing medical practice, and the application and translation of geroscience require seamless integration of basic, translational, and clinical researchers. This includes the identification of new biomarkers, novel molecular targets as potential therapeutic agents, and translational in vivo studies to assess the potential efficacy of new interventions.

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Article Synopsis
  • The study aimed to analyze how frequently doctors document mobility limitations in older adults during medical visits, identifying factors related to patients, physicians, and practice settings.
  • A cross-sectional analysis was performed using National Ambulatory Medical Care Surveys from 2012 to 2016, focusing on visits involving patients aged 65 and older, totaling 1.3 billion visits.
  • Results showed a low prevalence (2.4%) of documented mobility limitations, with older age and specific comorbidities being more likely to be associated with such documentation, while male gender and certain health conditions were less likely.
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Changes in old age that contribute to the complex issue of an increased metabolic cost of walking (mass-specific energy cost per unit distance traveled) in older adults appear to center at least in part on changes in gait biomechanics. However, age-related changes in energy metabolism, neuromuscular function and connective tissue properties also likely contribute to this problem, of which the consequences are poor mobility and increased risk of inactivity-related disease and disability. The U.

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Objective: To identify attributes targeted by rehabilitative treatment within which improvements lead to short- and long-term changes in mobility. Maintaining independence in mobility is important to many older adults and is associated with critical outcomes such as aging in place, morbidity, and mortality.

Design: The Live Long Walk Strong rehabilitation study is a phase 2 single-blind, randomized controlled trial.

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