Large size fibrillar bundles of the Alzheimer amyloid beta-protein.

Self-assembly of amyloid beta-protein (Abeta) and its deposition into senile plaques are distinctive features of Alzheimer's disease. Abeta forms typical linear aggregates known as amyloid fibrils, with a diameter of a few tens of nanometers and a length spanning from hundreds of nanometers to micrometers. Fibrils eventually assemble into large size clusters and precipitate in vivo in the brain deposits.

A statistical light scattering approach to separating fast and slow dynamics: application to a model system.

Light scattering is a powerful technique to study the structural and dynamical properties of biomolecular systems or other soft materials such as polymeric solutions and blends or gels. An important application of this technique is the study of the kinetics of formation of supramolecular structures. However, in such cases, the system under study is rapidly changing, and consequently the integration time for each measurement is limited.