Publications by authors named "Jennifer Baltazar"
Duplication 15q (dup15q) syndrome is the most common genetic cause of autism spectrum disorder (ASD). Due to a higher genetic and phenotypic homogeneity compared to idiopathic autism, dup15q syndrome provides a well-defined setting to investigate ASD mechanisms. Previous bulk gene expression studies identified shared molecular changes in ASD.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores converting adult human skin fibroblasts (FBs) into induced neurons (iNs) without using Noggin, aiming to make the process more efficient and cost-effective for disease modeling purposes.
- - Researchers focused on the transforming growth factor-β signaling pathway, identifying ALK2 as a key player in the fibroblast-to-neuron transition and tested the selective ALK2-inhibitor, DMH1, as a potential alternative to Noggin.
- - Results showed that using DMH1 improved conversion efficiencies and produced high-quality iNs with essential neuronal features, yielding similar outcomes to those achieved with Noggin but at a significantly reduced cost.