Balancing concern for other with concern for self: links between unmitigated communion, communion, and psychological well-being.

Previous research has demonstrated the importance of distinguishing between positive (communion) and negative (unmitigated communion) characteristics when investigating the relation between traditional feminine gender roles and psychological adjustment. However, previous work has relied on cross-sectional analysis of self-reported unmitigated communion and self-reported emotional distress. The present series of studies was designed to address this limitation by using multiple methodologies to examine the relation between unmitigated communion (UC) and psychological adjustment.

Heterozygosity for the BLM(Ash) mutation and cancer risk.

Bloom syndrome is an autosomal recessive disorder whose characteristics include an increased risk for many types of cancers. In contrast to the homozygous mutations of Bloom syndrome, heterozygous carriers of BLM mutations may be at increased risk for developing colorectal cancer. We have screened 2,333 Jewish individuals, including 497 individuals with colorectal cancer, 125 with adenomatous polyps, 767 with noncolorectal cancers and 944 controls for the truncating BLM(Ash) founder mutation.

A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families.

The 185delAG and 5382insC founder mutations account for the majority of mutations identified in BRCA1 in Ashkenazi Jewish breast and breast-ovarian cancer families. Few non-founder BRCA1 mutations have been identified to date in these families. We initially screened a panel of 245 Ashkenazi Jewish breast-ovarian cancer families with an affected proband and at least one other case of breast or ovarian cancer for founder mutations in BRCA1 and BRCA2.