Quantitative analysis of neural stem cell migration and tracer clearance in the rat brain by MRI.

Purpose: This study describes a quantitative method to estimate the migratory capacity of neural stem cells (NSCs) using magnetic resonance imaging.

Procedures: NSCs were labeled with ferumoxides and injected stereotaxically into the corpus callosum of the normal rat brain. Control subjects received either free ferumoxides or nonviable labeled cells.

Open access to biomedical engineering publications.

Scientific research is disseminated within the community and to the public in part through journals. Most scientific journals, in turn, protect the manuscript through copyright and recover their costs by charging subscription fees to individuals and institutions. This revenue stream is used to support the management of the journal and, in some cases, professional activities of the sponsoring society such as the Institute of Electrical and Electronics Engineers (IEEE).

Assessment of vessel size by MRI in an orthotopic model of human pancreatic cancer.

Pancreatic cancer is a devastating disease with no cure. Therapies that target the tumor vasculature are promising new treatment strategies. Magnetic resonance imaging (MRI) can non-invasively determine a vessel size index and a blood volume fraction to characterize the vascular compartment in a tumor.

Magnetically targeted viral envelopes: a PET investigation of initial biodistribution.

Gene and drug therapy for organ-specific diseases in part depends on the efficient delivery to a particular region of the body. We examined the biodistribution of a viral envelope commonly used as a nanoscale gene delivery vehicle using positron emission tomography (PET) and investigated the magnetic alteration of its biodistribution. Iron oxide nanoparticles and (18)F-fluoride were encapsulated by hemagglutinating virus of Japan envelopes (HVJ-Es).

Age-related decrease in axonal transport measured by MR imaging in vivo.

Axonal transport is a crucial process for neuronal homeostasis and cell functions. In vitro studies have indicated transport rates decrease with age. Disruption of axonal transport has been implicated in age-associated neurodegenerative disorders.

In vivo imaging of functional disruption, recovery and alteration in rat olfactory circuitry after lesion.

Compensatory changes following disruption of neuronal circuitry have been indicated by previous imaging studies of stroke and other brain injury, but evidence of the pathways involved in such dynamic changes has not been shown in vivo. We imaged rats before and after lesion-induced disruption of the lateral olfactory tract to investigate the subsequent recovery and/or reorganization of functional neuronal circuitry. Serial magnetic resonance imaging was performed following intranasal administration of a paramagnetic track tracer Mn(2+).

Transfection of neuroprogenitor cells with iron nanoparticles for magnetic resonance imaging tracking: cell viability, differentiation, and intracellular localization.

Purpose: Magnetic resonance imaging (MRI) can track labeled cells in the brain. The use of hemagglutinating virus of Japan envelopes (HVJ-Es) to effectively introduce the contrast agent to neural progenitor cells (NPCs) is limited to date despite their high NPC affinity.

Procedures: HVJ-Es and Lipofectamine 2000 were compared as transfection vehicles of superparamagnetic iron oxide (SPIO).

Statistical mapping of functional olfactory connections of the rat brain in vivo.

The olfactory pathway is a unique route into the brain. To better characterize this system in vivo, rat olfactory functional connections were mapped using magnetic resonance (MR) imaging and manganese ion (Mn2+) as a transport-mediated tracer combined with newly developed statistical brain image analysis. Six rats underwent imaging on a 1.