Disruption of auditory and visual attention in schizophrenia.

Disruption of attention is a hallmark symptom of schizophrenia, and event-related potentials have been instrumental in studying this cognitive deficit. Event-related potentials (ERPs) have been used to study attention and its disruption in schizophrenia, with the most common finding of a reduced P300 component in auditory tasks. Some studies have found sparing of the P300 in visual attention, but reduction of an earlier attention-sensitive N2b, suggesting that the N2b may be a more sensitive index of attention disruption in schizophrenia.

Event-related potentials to auditory and visual selective attention in schizophrenia.

Background: Prior studies have shown a consistent reduction of the auditory P300 in schizophrenia, while the visual attention findings have been mixed. Both the auditory and visual N2b, an earlier, modality-specific attention index, are reduced in schizophrenia, sometimes despite sparing of the visual P300. Thus there may be a dissociation between the N2b and P300 attention effects in auditory and visual modalities in schizophrenia.