Publications by authors named "Jenni Ross"
Article Synopsis
- Protein crystallography is a powerful method for uncovering biological structures, but creating suitable crystals can be very challenging.
- A new hybrid predictive model combines both experimental data and information derived from protein sequences, utilizing unique variables like R(30), which represent protein characteristics at different temperatures.
- This hybrid model outperforms traditional sequence-based methods, making it a valuable tool for guiding structural genomics and enhancing the work of structural biology labs.
Purine nucleoside phosphorylases (PNPs) and uridine phosphorylases (UPs) are closely related enzymes involved in purine and pyrimidine salvage, respectively, which catalyze the removal of the ribosyl moiety from nucleosides so that the nucleotide base may be recycled. Parasitic protozoa generally are incapable of de novo purine biosynthesis; hence, the purine salvage pathway is of potential therapeutic interest. Information about pyrimidine biosynthesis in these organisms is much more limited.
View Article and Find Full Text PDFThe 1.8 A resolution de novo structure of nucleoside 2-deoxyribosyltransferase (EC 2.4.
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