Publications by authors named "Jenni Martinez Villarruel Hinnerskov"
Background: Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes among others. This study aims to investigate systemic complement proteins and Cregs in AMD stages and their association with treatment response in neovascular AMD (nAMD).
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- The study investigates how certain structural biomarkers identified through Optical Coherence Tomography (OCT) relate to changes in retinal sensitivity in patients with intermediate age-related macular degeneration (iAMD).
- A total of 45 eyes from 23 patients were analyzed using OCT scans and microperimetry, focusing on risk factors like intraretinal hyperreflective foci (HRF) and drusen volume, among others.
- Results showed that retinal sensitivity significantly decreased in the presence of these OCT risk factors, suggesting that monitoring these biomarkers could help predict disease progression in iAMD patients.
Purpose: Geographic atrophy (GA) secondary to age-related macular degeneration is a progressive retinal degenerative disease. Systemic chemokine receptors and known risk-associated single-nucleotide polymorphisms have been associated with GA pathogenesis. Because halting progression is pivotal for patients, we investigated the association of candidate chemokine receptors and progression rate (PR) of atrophic lesions in patients with GA.
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- Geographic atrophy (GA) severely affects vision in the elderly, leading to significant difficulties in daily tasks like reading, and causing emotional distress such as fear and anxiety.
- Many patients lack sufficient information about GA and its prognosis, which exacerbates their challenges.
- Although the National Eye Institute Visual Function Questionnaire (VFQ) is commonly used to measure patients' quality of life, there's a lack of effective treatments that improve these outcomes in clinical settings.