Publications by authors named "Jenna M Williams"
J Proteome Res
August 2024
Article Synopsis
- The study investigates how the lipid composition (lipidome) in the central nervous system changes during the processes of demyelination and remyelination in a mouse model called -iCKO-.
- Through mass spectrometry and longitudinal analysis over 24 weeks, researchers found unique lipid profiles for the brain and spinal cord, indicating different abilities to regenerate myelin.
- Notably, higher levels of specific lipids (plasmalogens) were found during early demyelination, and some lipids changed in response to a remyelinating drug, suggesting potential biomarkers for future research in this area.
Article Synopsis
- The study focuses on how lipid-rich myelin debris is processed in the central nervous system (CNS) during demyelination and remyelination, using a genetic mouse model called -iCKO- mice.
- It provides a detailed lipidomic profile over 24 weeks, revealing distinct differences in remyelination capabilities between the brain and spinal cord, as shown through data analysis methods like principal component analysis (PCA).
- Key findings include an increase in specific lipids, like plasmalogens, during early demyelination stages, and the identification of potential biomarkers linked to remyelination when treated with a remyelinating drug.
