Incidence, Course, and Characteristics of Hydralazine-Associated Tachycardia During Phase I Postanesthesia Recovery.

Purpose: This study aims to characterize the development of tachycardia after intravenous hydralazine administration during Phase I recovery.

Design: Retrospective observational study design.

Methods: The medical records of 745 adult surgical patients who were administered hydralazine during Phase I recovery between January 1, 2010 and December 31, 2014 were electronically reviewed to characterize episodes of tachycardia.

Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth.

We have studied the effects of overexpression of superoxide dismutase (SOD), a tumor suppressor protein that dismutes superoxide radical to H2O2, on breast cancer cell growth in vitro and xenograft growth in vivo. No previous work has directly compared the growth-suppressive effects of manganese SOD (MnSOD) and copper-zinc SOD (CuZnSOD). We hypothesized that either adenoviral MnSOD (AdMnSOD) or adenoviral CuZnSOD (AdCuZnSOD) gene therapy would suppress the growth of human breast cancer cells.