Comparison of volume guarantee and volume-controlled ventilation both using closed loop inspired oxygen in preterm infants: a randomised crossover study (CLIO-VG study).

Objective: The objective of this study was to compare two different modes of ventilation in maintaining oxygen saturation (SpO2) in target range (90%-95%) in ventilated preterm infants cared for with automatic control of oxygen delivery (A-FiO2).

Design: A single-centre randomised crossover study.

Settings: A level III neonatal intensive care unit.

Preterm children with suspected cerebral palsy at 19 months corrected age in the Canadian neonatal follow-up network.

Background: The ability to definitively diagnose cerebral palsy (CP) at 18-24 months is unknown.

Aims: To describe very preterm children who, at 19 months, have suspected CP defined as neither having a definitive diagnosis of CP nor no CP and compare them with children with and without CP.

Study Design And Methods: Longitudinal national cohort study of births <29 weeks' gestation with linked Canadian Neonatal Network and Canadian Neonatal Follow-up Network data with 19 month assessments and 3-year questionnaires (Ages and Stages-3 and Health Status Classification System-Preschool).

Outcomes of infants with a birthweight less than or equal to 500 g in Northern England: 15 years experience.

Aim: We aimed to evaluate mortality and short-term neonatal morbidity of babies born ≤500 g cared for in the Northern Neonatal Network over a 15-year period.

Method: Using regional databases, we identified all live-born babies ≥22 weeks gestation and ≤500 g, in North East England and North Cumbria from 1998 to 2012. We quantified major neonatal morbidities and survival to one year.

Preterm birth and subsequent insulin sensitivity: a systematic review.

Objective: The incidence of preterm birth is increasing worldwide. Evidence suggests that in later life these children are at increased risk of 'metabolic syndrome', which is itself associated with reduced insulin sensitivity (IS). We carried out a systematic review to examine whether preterm birth is associated with later changes in IS and whether a difference exists between those born small-for-gestational age (SGA) and appropriate-for-gestational age (AGA).