Surgeon's Guide to Facial Soft Tissue Filler Injections: Relevant Anatomy and Safety Considerations.

The purpose of this study is to provide a review of the relevant facial anatomy related to soft tissue filler injections. Facial fillers are used daily in our clinical practice. Although their use is safe and predictable, adverse events do occur.

Enzymatic recycling of ascorbic acid from dehydroascorbic acid by glutathione-like peptides in the extracellular loops of aminergic G-protein coupled receptors.

The intracellular recycling of ascorbic acid from dehydroascorbic acid by the glutathione-glutathione reductase system has been well-characterized. We propose that extracellular recycling of ascorbic acid is performed in a similar manner by cysteine-rich, glutathione-like regions of the first and second extracellular loops of some aminergic receptors including adrenergic, histaminergic, and dopaminergic receptors. Previous research in our laboratory demonstrated that ascorbic acid binds to these receptors at a site on their first or second extracellular loops, significantly enhancing ligand activity, and apparently recycling hundreds of times their own concentration of ascorbate in an enzymatic fashion.

Tartaric Acid Enhances Adrenergic Receptor Activity: Test of a General Theory of Extracellular Aminergic GPCR Enhancer Discovery.

Several different classes of compounds enhance the potency of aminergic receptor ligands three-fold or more and increase their duration of activity up to ten-fold. These enhancers include the vitamins ascorbic acid and folic acid, chelators such as ethylenediaminetetraacetic acid, corticosteroids, and opioids, opiates and opiate antagonists. We have previously demonstrated that all of these classes of enhancers share a common molecular motif consisting of a linear array of two hydroxyls and a carbonyl.