Publications by authors named "Jenna C Holler"
J Clin Transl Sci
October 2024
Article Synopsis
- Major risk factors for urothelial cell carcinoma (UCC) include smoking and occupational exposures, but 30% of cases are still unexplained; pet dogs may serve as models for studying non-tobacco UCC risk due to their similar disease behavior.
- Researchers exposed human and canine urothelial cells to acrolein and inorganic arsenic to explore DNA damage, finding specific genotoxic thresholds for each substance.
- The study indicated that non-tobacco exposure to acrolein could lead to early DNA damage in both humans and dogs, warranting further investigation into these chemical exposures in relation to UCC.
