Publications by authors named "Jenna A Menadue"
Front Cell Dev Biol
February 2023
Article Synopsis
- - Identifying genes linked to human pancreatic beta cell maturation can enhance our understanding of islet development and improve methods for generating functional stem cell-derived islets (SC-islets).
- - The study highlights Urocortin-3 (UCN3) as a beta cell maturation marker found in human fetal islets, but it does not indicate functional maturity in SC-islets, which lack proper glucose-stimulated insulin secretion.
- - Additional candidate genes like CHGB, G6PC2, FAM159B, GLUT1, IAPP, and ENTPD3 were found to correlate with the developmental timeline of functional maturation, while ERO1LB, HDAC9, KLF9, and ZNT8
