Publications by authors named "Jenn-Hwa Liu"
Phthalates, such as butyl benzyl phthalate (BBP), di-n-butyl phthalate (DBP), and their metabolites (mono-buyl phthalate [MBP], mono-benzyl phthalate [MBzP] and phthalic acid [PA]), are known to obstruct normal development in mammals. BBP and DBP have been reported to have estrogenic activity, while MBP and MBzP exhibit weak or no estrogenic effects. We previously showed that BBP and DBP have inhibitory roles on nicotinic acetylcholine receptors.
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- para-Dichlorobenzene (DCB) is an industrial chemical recognized as an indoor air contaminant with potential toxicity effects on both workers and the general public.
- Research in human neuroblastoma SH-SY5Y cells reveals that DCB causes a significant rise in cytosolic calcium concentration at levels above 200 microM, which cannot be countered by certain receptor antagonists but can be partially inhibited by thapsigargin.
- Additionally, DCB was found to inhibit calcium concentration increases triggered by stimulation of nicotinic and muscarinic acetylcholine receptors, suggesting it disrupts their normal functional activities.
Clear cell hepatocellular carcinoma (HCC) is an uncommon variant of HCC. It is considered to have a better prognosis than non-clear cell HCC, but recent large studies show that there is some controversy. DNA image cytometry reveals diploid and non-diploid DNA content tumors that have different pleomorphisms and mitosis corresponding to different prognoses.
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