ED Nurse-Led Code Sepsis to Reduce Time to Antibiotics.

Background: Delays in sepsis recognition contribute to delays in antibiotic administration, which lead to increased morbidity and mortality in patients with sepsis. Our objective was to create an Emergency Department (ED) Code Sepsis Nurse-led team to reduce the time to antibiotics and mortality in patients with sepsis.

Methods: This initiative was implemented at a community hospital in Southern California in response to previous undesirable sepsis outcomes.

Proteoglycan 4 (Lubricin) and regulation of xanthine oxidase in synovial macrophage as a mechanism of controlling synovitis.

Background: Synovial macrophages (SMs) are important effectors of joint health and disease. A novel Cx3CR1 + TREM2 + SM population expressing the tight junction protein claudin-5, was recently discovered in synovial lining. Ablation of these SMs was associated with onset of arthritis.

Ring-opening polymerization of ε-caprolactone with a macrocyclic tetracarbene indium complex.

The first chiral tetracarbene indium(III) complexes have been synthesized by employing a rigid dianionic macrocyclic tetra-NHC ligand. The macrocyclic indium tetra-NHC bromide and ethoxide complexes are structurally similar to analagous salen complexes. The indium ethoxide complex effectively promotes living ring-opening polymerization of ε-caprolactone at room temperature.

Updating methods for artificial intelligence-based clinical prediction models: a scoping review.

Objectives: To give an overview of methods for updating artificial intelligence (AI)-based clinical prediction models based on new data.

Study Design And Setting: We comprehensively searched Scopus and Embase up to August 2022 for articles that addressed developments, descriptions, or evaluations of prediction model updating methods. We specifically focused on articles in the medical domain involving AI-based prediction models that were updated based on new data, excluding regression-based updating methods as these have been extensively discussed elsewhere.

Assessing the Value of New Antimicrobials: Evaluations of Cefiderocol and Ceftazidime-Avibactam to Inform Delinked Payments by the NHS in England.

Objectives: The UK has recently established subscription-payment agreements for two antimicrobials: cefiderocol and ceftazidime-avibactam. This article summarises the novel value assessments that informed this process and lessons learned for future pricing and funding decisions.

Methods: The evaluations used decision modelling to predict population incremental net health effects (INHEs), informed by systematic reviews, evidence syntheses, national surveillance data and structured expert elicitation.

How Canines Can Assist Our Patients with Diabetes: Diabetes Alert Dogs: What Are Their Capabilities?

Background: The canine olfactory system is used for tasks that greatly aid society, such as detecting explosives, finding lost persons, and detecting many diseases and abnormal blood sugar levels early. However, the reliability of detection of glycemic fluctuations is questionable.

Methods: We reviewed the literature on the capability of canines in detecting significant variations in blood sugar.

Switchable, chiral aluminium catalysts for ring opening polymerisations.

A switchable, solvent-free catalytic system was developed in which Al methyl aminebis(phenolate) catalysts selectively initiate the formation of a polyether from cyclohexene oxide under CO atmosphere or the ring opening copolymerisation (ROCoP) of cyclohexene oxide and CO through the addition of a PPNCl (bis(triphenylphosphine)iminium chloride) cocatalyst to form poly(cyclohexene carbonate).

Long-Term Safety and Efficacy of Macitentan in Inoperable Chronic Thromboembolic Pulmonary Hypertension: Results from MERIT and its Open-Label Extension.

Introduction: Evidence for use of pulmonary arterial hypertension targeted-therapies in patients with chronic thromboembolic pulmonary hypertension (CTEPH) is limited. In MERIT-1, the endothelin receptor antagonist macitentan improved hemodynamic and functional parameters versus placebo in patients with inoperable CTEPH over a 24-week double-blind (DB) period. Its open-label (OL) extension study (MERIT-2) provides long-term safety/efficacy data.

Effects of Extracted Pulse Proteins on Lipid Targets for Cardiovascular Risk Reduction: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Many clinical practice guidelines recommend dietary pulses for the prevention and management of cardiovascular disease and diabetes. The impact of extracted pulse proteins remains unclear. We therefore conducted a systematic review and meta-analysis of randomized controlled trials of the effect of extracted pulse proteins on therapeutic lipid targets.

Exploring the anatomy of using micro-computed tomography.

Micro-computed tomography (micro-CT) is an emerging tool in parasitology that can assist in analysing morphology and host-parasitic interactions. It is a non-destructive, cross-sectional imaging technique that offers good resolution and the ability to create three-dimensional (3D) reconstructions. Here, we used micro-CT to study , which is a zoonotic pentastome parasite that infects dogs and ruminants throughout the world.

Development and internal validation of prehospital prediction models for identifying intracerebral haemorrhage in suspected stroke patients.

Introduction: Distinguishing patients with intracerebral haemorrhage (ICH) from other suspected stroke cases in the prehospital setting is crucial for determining the appropriate level of care and minimising the onset-to-treatment time, thereby potentially improving outcomes. Therefore, we developed prehospital prediction models to identify patients with ICH among suspected stroke cases.

Methods: Data were obtained from the Field Administration of Stroke Therapy-Magnesium prehospital stroke trial, where paramedics evaluated multiple variables in suspected stroke cases within the first 2 hours from the last known well time.

Impact of travel distance on short-term outcomes in patients receiving treatment for urolithiasis: A population-based study.

Introduction: We aimed to assess the relationship between the distance traveled to receive treatment for urolithiasis and early outcomes.

Methods: This is a population-based study of patients who received interventions for urolithiasis in Ontario between 2003 and 2019 using administrative data. Patients were stratified into three groups according to the distance travelled.

Body Mass Management Practices of Olympic Weightlifting Athletes.

This study explored the body mass (BM) management practices among competitive male and female Olympic weightlifting athletes, hypothesizing that athletes compete in lighter weight categories than their habitual training weight (i.e., making weight).

Sex and gender considerations in cross-cultural traumatic stress studies.

Following the 1st Conference of the Global Collaboration on Traumatic Stress, the consortium committed to systematically integrating sex and gender considerations in their endeavours, which aligns with the 's Gender Policy. This initiative is vital for understanding trauma's complex impacts, but also presents significant challenges in cross-cultural research. This letter, co-authored by researchers from across the globe, outlines these challenges and proposes mitigation strategies.

Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors.

Pre-clinical murine and in vitro models have demonstrated that exercise suppresses tumour and cancer cell growth. These anti-oncogenic effects of exercise were associated with the exercise-mediated release of myokines such as interleukin (IL)-15. However, no study has quantified the acute IL-15 response in human cancer survivors, and whether physiological adaptations to exercise training (i.

Worldwide CTEPH Registry: Long-Term Outcomes With Pulmonary Endarterectomy, Balloon Pulmonary Angioplasty, and Medical Therapy.

Background: The European Chronic Thromboembolic Pulmonary Hypertension (CTEPH) registry, conducted between 2007 and 2012, reported the major impact of pulmonary endarterectomy (PEA) on the long-term survival of patients with CTEPH. Since then, 2 additional treatments for inoperable CTEPH have become available: balloon pulmonary angioplasty (BPA), and an approved oral drug therapy with the guanylate cyclase stimulator riociguat. The current registry aimed to evaluate the effect of these new therapeutic approaches in a worldwide context.

The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials.

The Portfolio Diet, a dietary pattern of cholesterol-lowering foods, is also rich in low glycemic index (GI) foods. While strong evidence supports clinically meaningful reductions in cholesterol, evidence on the relationship between the Portfolio Diet and diabetes management is lacking. To evaluate the relationship between the Portfolio Diet and glycated hemoglobin (HbA1c) as a determinant of glycemic control among adults living with type 2 diabetes mellitus (T2DM).