Clinical trials (CT) are essential for developing new medicines and require participant involvement, which is influenced by their attitudes and understanding of the trials.
A study at B.P. Koirala Institute of Health Sciences in Nepal assessed the knowledge and perceptions of 622 participants in a phase III CT, finding that a vast majority were literate, of indigenous backgrounds, and had not participated in a CT before.
Results showed that 91% of participants had adequate knowledge and 95.7% had a positive perception of CT, with most joining for disease protection and believing the trials benefit humanity, suggesting the need for future studies on knowledge before and after participation.
The bioaccumulation of the neurotoxin methylmercury (MeHg) in freshwater ecosystems is thought to be mediated by both water chemistry (e.g., dissolved organic carbon [DOC] and dissolved mercury [Hg]) and diet (e.