Chromosome-level organization of the regulatory genome in the Drosophila nervous system.

Previous studies have identified topologically associating domains (TADs) as basic units of genome organization. We present evidence of a previously unreported level of genome folding, where distant TAD pairs, megabases apart, interact to form meta-domains. Within meta-domains, gene promoters and structural intergenic elements present in distant TADs are specifically paired.

Binding modes of potential anti-prion phytochemicals to PrP structures in silico.

Background: Prion diseases involve the conversion of a normal, cell-surface glycoprotein (PrP) into a misfolded pathogenic form (PrP). One possible strategy to inhibit PrP formation is to stabilize the native conformation of PrP and interfere with the conversion of PrP to PrP. Many compounds have been shown to inhibit the conversion process, however, no promising drugs have been identified to cure prion diseases.