Magnetically-active Pickering emulsions stabilized by hybrid inorganic/organic networks.

Magnetically-active hybrid networks (MHNs) are complex inorganic/organic composite materials that have been synthesized from the coupling of amine-functionalized iron oxide nanoparticles (amine-IONs) and pre-assembled shell crosslinked knedel-like (SCK) polymeric nanoconstructs. The intricate structure of these materials is composed of several inter-connected bundles of SCKs covalently bound to amine-IONs, which afford them magnetic responsivity. The MHNs were originally designed to sequester complex hydrocarbons from water; however, they have displayed a remarkable ability to form stable Pickering emulsions between organic solvents and water, upon mechanical stimulus.

In vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging.

Nanoparticles (NPs) play expanding roles in biomedical applications including imaging and therapy, however, their long-term fate and clearance profiles have yet to be fully characterized in vivo. NP delivery via the airway is particularly challenging, as the clearance may be inefficient and lung immune responses complex. Thus, specific material design is required for cargo delivery and quantitative, noninvasive methods are needed to characterize NP pharmacokinetics.

Holistic assessment of covalently labeled core-shell polymeric nanoparticles with fluorescent contrast agents for theranostic applications.

The successful development of degradable polymeric nanostructures as optical probes for use in nanotheranostic applications requires the intelligent design of materials such that their surface response, degradation, drug delivery, and imaging properties are all optimized. In the case of imaging, optimization must result in materials that allow differentiation between unbound optical contrast agents and labeled polymeric materials as they undergo degradation. In this study, we have shown that use of traditional electrophoretic gel-plate assays for the determination of the purity of dye-conjugated degradable nanoparticles is limited by polymer degradation characteristics.

Robust magnetic/polymer hybrid nanoparticles designed for crude oil entrapment and recovery in aqueous environments.

Well-defined, magnetic shell cross-linked knedel-like nanoparticles (MSCKs) with hydrodynamic diameters ca. 70 nm were constructed through the co-assembly of amphiphilic block copolymers of PAA20-b-PS280 and oleic acid-stabilized magnetic iron oxide nanoparticles using tetrahydrofuran, N,N-dimethylformamide, and water, ultimately transitioning to a fully aqueous system. These hybrid nanomaterials were designed for application as sequestering agents for hydrocarbons present in crude oil, based upon their combination of amphiphilic organic domains, for aqueous solution dispersibility and capture of hydrophobic guest molecules, with inorganic core particles for magnetic responsivity.